Antiproliferative activities of halogenated pyrrolo[3,2-d]pyrimidines
نویسندگان
چکیده
منابع مشابه
Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines.
The in vitro evaluation of thieno[3,2-d]pyrimidines identified halogenated compounds 1 and 2 with antiproliferative activity against three different cancer cell lines. A structure activity relationship study indicated the necessity of the chlorine at the C4-position for biological activity. The two most active compounds 1 and 2 were found to induce apoptosis in the leukemia L1210 cell line. Add...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry
سال: 2015
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2015.06.025